Mast Cell Activation Syndrome

Almost no-one has heard of it, but as many as one in five of us are suffering from it.

There isn’t a single historical reference to this condition, in all of the many learned medical texts, so it has apparently arrived from NOWHERE.

It causes considerable impairment, both mentally and physically, and it exists amongst us everywhere. But, despite its apparent presentation, hardly anyone seems able to see it.

Mast Cell Activation Syndrome is gravely debilitating, and can affect every system of the body. In many ways, the development of Mast Cell Activation Syndrome equates to an increased intollerance to life, as we know it, making the sufferer retreat, more and more, from the main ebbs and flows of existance.

Mast Cell Activation Syndrome simply makes us less able to “show up” in the world, robbing us of being an active part of our communities.

Affecting up to 20% of the population, if not more, this condition qualifies as a pandemic several times over, yet no-one is talking about it.

It’s time to change that!

This is especially true at this point in time. It is growing increasingly clear that WE ARE ALL heading in the direction through we will also acquire Mast Cell Activation Syndrome, and start suffering from its attendent neurodegenerative disorders.

What This Article Covers

This article serves as a comprehensive overview of the causes of Mast Cell Activation Syndrome, a condition that is underpinned by the chronic malfunctioning of our immune systems. These then lead to multifactoral issues that seriously undermine quality of life, and can progress to potentially fatal outcomes, over time.

It also explains why these symptoms are experienced by those suffering from Mast Cell Activation Syndrome, and those who are en-route to this severe condition.

Additionally, it outlines powerful natural protocols to:

• Boost immunity
• Quiet the body & mind
• Reduce systemic inflammation
• Contend with chronic infections
• Reduce toxic burdens to revitalise energy levels
• Improve cognitive function
• Regain emotional health
• Reverse chronic painful conditions

The Multiple Symptoms Of Mast Cell Activation Syndrome

Mast Cell Activation Syndrome is a long-term inflammatory condition, caused by chronic immune system stimulation.

It is very difficult to diagnose, as no two cases of MCAS are identical. Plus, in many ways, it is very similar to other chronic inflammatory conditions, including 150+ autoimmune conditions, which exhibit many of the same symptoms.

Mast Cell Activation Syndrome appears to gravitate towards our individual biological weaknesses leading to a multifactoral expression of symptoms that are unique to each individual.

However, inflammation is always present. This is because any form of immune response is inflammatory in nature.

Ultimately, Mast Cell Activation Syndrome is an impairment of the immune functions of the body. More specifically, it is an over-activation of the body’s natural immune system, leading to a slew of different symptoms. These symptoms often include the following, but typically, most people will only display some of the symptoms listed, not all…

• Chronic inflammation
• Increased susceptibility to catching colds and flu
• Slow to heal from injuries
• Slow to recover from illnesses
• Brain fog + forgetfulness + memory loss
• Allergies, including food allergies and environmental allergies (dust, mould & fragrance)
• Medication allergies
• Intollerant to stress
• Mould intollerant
• Neurologically sensitive to the point of overwhelm
• Temperature regulation issues
• Digestive issues
• Respiratory Issues
• Urinary issues
• Skin problems
• Urinary tract infections
• Mental & emotional health issues: anxiety & depression and panic attacks
• Extreme allergic reactions
• Chronic pain
• Severe diarrhoea
• Fatigue
• Headaches

What Are Mast Cells?

Mast cells are immune cells, created in the bone marrow, which then migrate to all other areas of the body. Mast cells line the peripheral interfaces between our body and the rest of the world.

Mast cells, when functioning normally, mediate acute allergic, immune, and inflammatory reactions.

Mast cells are heterogeneous, (diverse in character or content), robust, and granulated. They inhabit specific sites within our bodies via a number of different mechanisms:

• Proliferation
• Increased recruitmen
• Iincreased survival
• Increased rate of maturation from its progenitors, (what the mast cells, in question, descend or originate from)

They are found on our:

• Skin
• Upper respiratory tract & mouth
• Gastrointestinal tract
• Intersticial linings of the brain, creating the blood brain barrier
• Urinary system
• Nervous system
• Blood vessels – venal system

The reason why mast cells inhabit all of the areas of the body that interface with the world is because they are there to guard against foreign invaders. These can include:

• Viral infections
• Bacterial infections
• Yeast & mould infections
• Parasitic infections
• Medical interventions: most drugs are inherentley toxic. Some medical procedures contain neurodegenerative constituents, like heavy metals, such as lead, tin, mercury & aluminium found in injections + the mercury in amalgam fillings
• Environmental toxins: fragrances + synthetic chemicals in persol care products, cleaning products, lifestlye products (scented candles + reed diffusers etc) + toxic soft furnishings (pillows + mattresses + sofas + cushions + floor coverings + curtains, etc) + industrial contaminants + synthetic farming products (petrochemical fertilisers & herbicides) + fire retardants used in home furnishings etc…
• Allergens
• Leaky gut – inflammatory
• Oral microbiom – biofilms + infections
• Sinusitis – mould + bacterial + viral infections
• Tick born illness
• Too much stress
• Non-native EMF – synthetic electromagnetic fields from wireless devices
• Dirty electricity – dissonant circuitry that undermines synaptic and energetic functions of the body

Mast Cells Are A Big Part Of Our Natural Immunity

Under normal circumstances, our mast cells protect us against bacterial, viral, fungal and parasitic infections. They also mount a histamine response to counter allergens.

Mast cells will normally field “invadors”, and mount an innate immune response to deal with them. When functioning normally, our mast cells are activated periodically, when required.

Mast cells are filled with mediators, which are chemical messengers, that are released to mount this inate immune response.

Mediators are inflammatory, which means that inflammation is a natural part of every immune response.

Once the invasion has been dealt with, mast cells will return to normal function, and the inflammation caused by the immune response will die down.

Unfortunately, if we are dealing with too many environmental and emotional insults, our mast cells can turn on permanently, and remain in a state of red alert, indefinitely. When this happens, our hyper-vigilant mast cells cause chronic systemic inflammation and pain. It also leaves us immune-compromised.

Ironically, hyper-vigilant mast cells end up contributing to the problem they are actually meant to solve. This is known as Mast Cell Activation Syndrome.

When Mast Cells Go Rogue

The mast cells of a Mast Cell Activation Syndrome sufferer become hypervigilant, and remain in a permanently activated state.

This often occurs after dealing with an overwhelming level of infection, toxicity and / or stress.

Hypervigilance leads to hypersensitivity, with mast cells increasingly perceiving normal things as a threat.

Even changes in temperature, and our normal, healthy food can begin to trigger a major response.

This is why people with Mast Cell Activation Syndrome develop chronic inflammtion, which is the underlying feature of all autoimmune conditions and neurodegenerative disorders.

When mast cells are constantly releasing inflammatory mediators it also results in vagal dysfunction, limbic region activation and the cell danger response.

The vagus nerve, whilst also performing many other functions within the body, regulates our fight or flight and rest and digest responses.

The vagal dysfunction in those suffering from Mast Cell Activation Syndrome means that they become locked in a state of fight or flight. This inability to turn off the fight or flight response leads to all manner of other issues.

This is because the immune system and digestive system switches off when we are locked in fight or flight mode.

Learn more about the vagus nerve in: Vagal Breathing For Relaxation & Optimal Immunity

The progression of MCAS can take different paths. Some individuals report a lifetime of subtle symptoms that suddenly worsen after a specific trigger event.

These patients often realize, in retrospect, that they had been dealing with minor manifestations of the condition for years before a major event pushed their system over a threshold.

Others can identify a clear starting point for their symptoms, often following a severe illness or significant life stress.

What makes MCAS particularly challenging is that once mast cells become dysfunctional, they may continue to react inappropriately even after the initial trigger is removed. This creates a chronic condition that requires ongoing management rather than a simple one-time treatment.

The Athletic Paradox

An interesting aspect of MCAS, that challenges conventional understanding, is its occurrence in seemingly healthy, athletic individuals.

Many MCAS patients were highly functional before their condition became apparent, including professional athletes and other physically active individuals. However, subtle signs of an underlying dysfunction are often evident when medical histories are reviewed.

Although more able to compensate for their mast cell dysfunction, athletic types are still just as susceptible to a major triggering event.

Lifestyle & MCAS

Lifestyle choices, and an increasingly toxic world are the key contributors to developing MCAS, although prior infections and illnesses can play a part. Genetics can also contribute in terms of predisposing certain people to developing Mast Cell Activation Syndrome.

For example, certain genes are associated with an increased susceptibility to fungal infections, including those caused by mould, (mycotoxic infection). It is estimated that one in four people in the UK have HLA-DR/DQ gene variations.

These genes, which are involved in the innate immune response, can influence how the body reacts to fungal / mould pathogens. More specifically, they impede the natural immune response, and slow down mycotoxin detoxification, allowing for a greater susceptibility to long-term mould-related illnesses.

HLA-DR/DQ genes are related to the complement system, HLA (Human Leukocyte Antigen), and cytokine signaling pathways.

The HLA–DR/DQ isotype alleles are linked to mycotoxins susceptibility due to the lack of proper immune response; individuals with these alleles are poor eliminators of mycotoxins from their system.

Source: HLA gene variations and mycotoxin toxicity: Four case reports: https://link.springer.com/article/10.1007/s12550-023-00517-y

Complex Symptomology Of MCAS

There are are a great number of factors influencing the development of Mast Cell Activation Syndrome, and myriad ways in which it gains expression. This makes it very difficult to diagnose, and to treat.

As symptoms vary from one case to another, there is a need to take an individual approach to understanding, diagnosing and treating MCAS.

MCAS looks different from one person to another due to:

• Individual health status, (including personal predispositions and preconditions)
• Differing toxic exposures
• Different lifestyle choices

Mast Cell Activation Syndrome is thus very difficult to diagnose, but a diagnosis is required before natural or allopathic treatment protocols can be undertaken by a professional.

However, left unchecked, MCAS can develop into full-blown autoimmunity and neurodegenerative disorders. So it is important that the development of this condition is not ignored.

We can, of course, attempt to deal with the underlying issues assciated with a suspected case of MCAS ourselves, whilst we wait for the medical profession to diagnose us eventually…

MCAS is effectively the body in overwhelm… so reducing the reasons why it is overwhelmed, is obviously the way forward… But, once triggered, it can be difficult to get bodily systems to calm down again.

It is much better to take heed of the signs that we may be travelling in an MCAS direction and then head them off at the pass!

Key Symptoms Of Mast Cell Activation Syndrome

A lot of people with Mast Cell Activation Syndrome will have allergies and chemical sensitivities.

Allergies and intolerances are often seasonal allergies or food allergies / intolerances, etc. Respiratory abnormalities, including excessive mucous formation, sneezing, and stinging eyes, are the typical symptoms of seasonal allergies.

Urticaria, comminly known as hives, is an extreme allergic reaction caused by many different types of allergic stimuli.

Asthma is a form of non-seasonal respiratory allergic reaction.

All of these allergic responses have an inflammatory component, but their expression exceeds a simple inflammatory response, making them more complex. Nevertheless, these symptoms remain helpful for the purposes of diagnosis, as they are a demonstrable trigger of MCAS.

However, some people with Mast Cell Activation Syndrome don’t have any allergies at all. Nevertheless, in cases of MCAS where there are no allergies, there will still be systemic inflammation.

As the condition is triggered by so many differnt precursors, and has so many different expressions, it is known as an idiopathic condition, or one of unknown causes.

Fluctuation & Inconsistency Of MCAS Symptoms

Symptoms of MCAS can be exacerbated by increased levels of stress, poor digestion, poor sleep, and sleep dysregulation. It is also directly influenced by increased exposure to environmental toxins, including synthetic chemicals, and heavy metals. These can just as easily be found in the home as well as outside and other indoor environments.

The higher the level of toxicity we are exposed to, the greater the problem. Plus, we will often be exposed to complex combinations of the toxic precursors to MCAS, which will impact us all deifferently.

Certain individuals will be more prone to specific toxins than others.

There is a strong chance that the high level of exposure to scented products is significantly contributing to the development of MCAS, in many of us.

Environmental pollutants and pesticides are also exacting a considerable toll, as are prescription medications and other medical interventions.

There are also many aspects of our homes that are likely exacerbating MCAS symtomolgy, everything from synthetic products to mould.

Even a change in diet can lead to a worsening of symptoms. As can more stress at work, or within families and other interpersonal relationships.

Infections are also an issue. Each new infection, compounded by toxicity and stress, worsens the situation, resulting, for some, in the development of chronic immune activation / MCAS.

Ultimately, when this happens, Mast Cell Activation Syndrome then becomes the root cause of our systemic inflammation and discomfort / dis-ease.

Environmental Toxicity & MCAS

We are being liberally exposed to synthetic chemicals, which are in everything from cleaning and laundry poroducts, to scented candles.

*Please note, WE ARE ALL sensitive to, and are being poisoned by, the fragrances used in scented candles, reed diffusers, conventional air fresheners, incense, cleaning and laundry products and scented personal care products.

Plus, the toxins used to create the fragrances in these products, all bioaccumulate in everyone’s systems! As do the toxins from most other toxic exposures.

There are now many classes of what are being termed “Forever Chemicals”. These are present in everything from personal care products to our furniture… and are even found in the paints coating our walls… They are causing hormone disruption, emotional / mental health issues and cancers, alongside other life-threatening conditions. And, of course, they all contribute to the development of MCAS.

Forever chemicals are manmade, synthetic chemicals, and have a number of different acronyms, such as: PUFAs, PSAFs, PFOA and PFOS, etc… I have added an important article and Bloomberg video at the end of this section so you can do a deeper dive into the subject.

Many domestic pollutants are hormone disrupting, such as the chemicals being off-gassed by our soft furnishings. This includes the fire retardants used on everything from our cushions to our matresses and pillows.

Endocrine disrupting chemicals are in much of the food we consume, owing to the level of plastics in the food chain.

These endocrine disrupting chemicals are known as xenoestrogens or oestrogen mimicking substances. Common sources of xenoestrogens are the plastics in the food chain and the fire retardants on our sofas and pillows, etc.

Environmental chemicals, in the form of herbicides and pesticides, etc, are also an issue. Their widespread use means that we are all bioaccumulating these disruptive chemicals, either through airborne or direct exposure, through our water and food, etc.

It is almost impossible to remove these chemicals from our food before we consume it. This is especially true of “conventionally” grown products.

As these things bioaccumulate within our bodies, we are all susceptible to becoming overwhelmed by the toxic load. Consequently, it is highly likely that most of us will minimally develop a chemical sensitivity, at some point… But that, many of us will develop more serious health issues over time.

Chemical sensitivity will make it impossible for you to go into the average shop on the High Street, (all of which are synthetically fragranced in one way or another), without being adversely affected. Doing so will elevate your symptoms, and leave you feeling unwell. Symptoms such as nausea, light-headedness, and an increase in inflammatory pain, etc, will be felt by many.

Nor will you feel able to visit the homes of your friends who use plug-in air fresheners or scented candles and reed diffusers. You won’t even be able to tolerate the perfume that trails behind the person in front of you, as you walk down the street. The waft of perfume, or laundry detergent, or some other toxic concoction of synthetic chemicals, perhaps in their shampoo and conditioner, will make you feel unwell.

What makes matters worse, is that we are often using synthetic chemicals to disguise malodourous things, that are also harmful. Tragically, we have been educated to use synthetic fragrances to hide the smell of serious sources of underlying toxicity, such as mould, etc…

Not only does this add to the toxic burden, it also means that we are now accustomed to living in unsafe and unhealthy environments.

Mould, poor air quality and insanitary conditions can all have a devastating impact on our health. Even excess dust can cause an immune response / allergy. Or, more specifically, the feaces of the dust mites will elicit an immune response.

Allergies = an immune response.

Plus, a lot of the toxic chemicals are hiding out in the dust we are breathing in…

And, the long and short of it is that, life gets very inhibited when you develop mast cell activation syndrome. And, for many, whilst debilitating in itself, MCAS is often only the beginning of seriously deteriorating health.

There is a specific type of fiber, known as beta-glucan, that has been shown to reduce blood levels of PFAS chemicals, within just four weeks. The participants in the research who consumed beta-glucan were seen to have significant drops in legacy PFAS compounds like PFOA and PFOS. The most concentrated food sources of beta-glucan are oats and barley, but it can also be bought in supplement form.

• All The Stuff in Your Home That Might Contain PFAS ‘Forever Chemicals’ :: 13 minute read
• Documentary: The Forever Chemical Scandal | Bloomberg Investigates :: 48 mins
• Video: Forever Chemicals PFAS, PFOA, PFOS, BPA, Explained Clearly :: 22 mins

Prescription Drug Toxicity & MCAS

In addition, prescription drugs are often toxic, and vaccines are necessarily so, (all contain adjuvants which are toxic, to stimulate the immune respose).

Cancer treatments, such as chemotherapy, are profoundly toxic. Chemotherapy even actively destroys our innate immunity.

Our immune systems are what protect us from cancer, but when overwhelmed and dysregulated, our natural immune system is unable to contend with the clean-up operation, required for ridding the body of mis-formed cells.

Suppressing the innate immune system is now a common approach to practicing medicine. There are numerous immunosuppressant drugs available, with multiple applications.

Many immunosuppressant drugs target inflammation, caused by an overactive immune system. For example, Methotrexate, an antimetabolite, treats rheumatoid arthritis, and inflammatory skin conditions* like psoriasis. It is also used to impede the growth of cancer cells.

*All problem skin conditions are inflammatory, and fall under the autoimmune umbrella, including acne, eczema, dermatitis, roseacea and psoriasis.

Stress, poor diet, compromised digestion, insufficient sleep, and sleep dyregulation, are very clear precursors for all of these conditions.

Other commonly prescribed immunosuppressants are corticosteroids, which also decrease the inflammatory immune response. They are also used for inflammatory injuries.

Calcineurin inhibitors, often used for inflammatory skin conditions, also target inflammation by inhibiting t-cell activation, a key part of our immune response.

Monoclonal antibodies and mTOR inhibitors, etc, are often used for those with autoimmune conditions, and to prevent organ rejection in organ transplant patients.

This medical paper highlights the widespread use of immunosuppressant drugs: Prevalence of Immunosuppressive Drug Use Among Commercially Insured US Adults, 2018-2019 :: https://pmc.ncbi.nlm.nih.gov/articles/PMC8138687/

Even non-prescription drugs, like pain medications, often leave us immune compromised.

Autoimmune, neurologically degenerative diseases are linked to prescription drugs.

In addition, antibiotics, which destroy innate immunity, are still routinely used for extended periods to treat inflammatory skin conditions like acne. Anyone who has been prescribed antibiotics, especially long-term antibiotics, is very much immune-compromised, vulnerable to infection and a lot more likely to develop autoimmune conditions.

Thus, an over-reliance on prescription medications, and Western medical treatment, can pre-dispose us to developing Mast Cell Activation Syndrome.

Diet & MCAS

Diet is also an issue for many. Those eating highly processed foods, with many toxic ingredients, are extremely unlikely to be getting the nutrients needed to support the natural proccesses of their body.

A processed food diet leads to malnutrition. This is an unspeakable tradgedy in the modern world. We have never been more able to financially and logistically meet our dietary needs, but our dietary health is dreadfully inferior to that of our recent ancestors!

Highly processed foods also lead to gut dysregulation, and leaky gut, with all of its serious attendant inflammatory outcomes. Plus, processed food is usually loaded with sythetic chemicals, xenoestrogens and other toxins and contaminents.

Processed foods are also usually high in the following:

• Seed oils, when animal fats are much healthier
• Refined sugar, which is immensely neurotoxic, destroys gut health, and is deeply inflammatory
• Refined salt, which is stripped of its beneficial minerals. Plus, excessive sodium levels can lead to high blood pressure, and the risk of heart disease, stroke, and kidney disease.

Even foods that are touted as being healthy are causing us problems… Sadly, most of these can be purchased in health food shops. These include:

• Cereals
• Nut butters
• Plant based milks
• Soya products
• ‘Healthy’ snack foods
• Tinned goods
• Seed oils

Legumes, (lentils, peas and beans), can also be an issue. Many of us have intolerances to legumes and grains (cereals).

These foods are naturally inflammatory, so even if we are not intolerant of them, they are still contributing to systemic inflammation.

Our diets have changed dramatically since the industrial revolution. We have normalised the routine consuption of cereals, legumes, seed oils, and junk food, despite the negative impacts to our health.

From a commercial perspective, promoting these foods makes a lot of sense. Industrial farming methods have made unhealthy foods very cheap to produce, and available on a mass scale.

Sadly, producing healthy food is more costly, and presents a less attractive proposition to most consumers. This is especially true when most consumers don’t understand the negative health impacts of their food choices.

Water

There are many reason why our drinking water is more badly contaminated than ever before. Again commercial influences are playing their part, as is the global use of contaminents in farming, prescription medicines and product manufacturing in general:

• The chlorine in our water is a xenoestrogen.
• Flouride is neurotoxic, and has been definitively shown to be lowering IQ levels.
• Antibiotics and fake hormones are accumulating in our water supply. Neither the pill or antibiotics are broken down by the body, so once consumed they re-enter the water supply in the same form they enter the body.
• Farming residues from pesticide use.
• Industrial waste
• Reuse disposal
• Fracking

3% of the world’s water is drinking water (not salinated), with only c. 1% of freshwater being accessible to humans. A large proportion of the accessible freshwater has been contminated, rendering it unfit for human consumption, without first undergoing costly processing.

Even when water has been processed it contains many residues that undermine our health at a systemic level,

A good water filtration system is required to remove these contaminents. Unfortunately, water jugs are inadequate. (I use a Berkey water filter).

Sedentary Lifestyles & MCAS

Being exposed to the natural world, especially in a proactive way, through walking and cycling, is exceedingly important for us. Especially if we wend our way through woodland.

In woodland we are exposed to soil probiotics, which restore gut health, and phytoncides, released by the trees, which improve emotional health. (Phytoncides are found in a good number of essential oils.)

Sunlight exposure is also crucially important for several metabolic functions, dramatically improving our immune health and our ability to achieve a good night’s sleep.

Beach walking exposes us to negative ions, ozone, and archaea from the sea.

Archaea are microorganisms, similar to bacteria in size and simplicity, but radically different in molecular organisation. They are now believed to constitute an ancient intermediay group of microorganisms between bacteria and eukaryotes.

Eukaryotes are organisms consisting of a single cell, or number of cells, containing genetic material [DNA] in the form of chromosomes, within a distinct nucleus. Eukaryotes include all living organisms other than the eubacteria and archaea.

Eubacteria is the group of bacterium found mainly in the intestines of vertebrates, including humans, and is also responsible for soil health. They form a large group, typically possessing simple cells with rigid cell walls. Many have flagella, whip-like appendages that propel cells or organisms through fluids. This group is comprised of ‘true’ bacteria and cyanobacteria, as distinct from archaea.

Cyanobacteria are related to bacteria, but are capable of converting sun into energy, aka photosynthesis. They are the earliest known form of life on earth. The most commonly known forms of cyanobacteria are blue-green algae.

Eubacteria is essential for human health. Many of us are suffering digestive issues due to diminished populations and diversity of eubacteria in our guts. We cannot digest our food, nor mount fundamentally important processes within our bodies, without a healthy population of eubacteria.

We are completely reliant on the natural world for our health. Regular exposure to it is vitally important.

The archaea that we get from the sea are not critical for human health, as we understand it today. However, they improve diversity, and certainly have a role to play within our health.

These are just some of the reasons why inactivity and an indoor lifestyle are very detrimental to our health:

• Indoor air quality is far worse than that found outside.
• Being largely imobile negatively interferes with bodily processes at a systemic level.
• We are exposed to synthetic light instead of life-giving sunlight

Wireless Tech & MCAS

It is estimated that wireless technologies are undermining our immune function by about 40%. It does this through systemic inteference.

Wireless technology can affect mast cell activation syndrome by triggering mast cell degranulation and inflammation.

Studies show that electromagnetic fields (EMFs), from things like mobile phones, routers, baby monitors, and all other devices that support wireless signals, can increase mast cell numbers, degranulation, and the release of mast cell mediators like histamine, contributing to symptoms, such as;

• Pain
• Itching
• Oedema
• Inflammation
• Migraine
• Increased blood-brain barrier permeability
• Neuropsychiatric effects

Infections & MCAS

Repeated infections mean that the immune response is mobilised too often, and can lead to MCAS.

Viral, bacterial, fungal and parasitic infections can all trigger MCAS. But it’s often a combination of insults that lead to the full development of mast cell activation syndrome.

People can even be born with MCAS, or it can develop in childhood, due to multiple pathogenic, traumatic and toxic exposures.

Emotional Stress & MCAS

There are many things that stress us out, in the modern world:

• Information overload & the type of news we consume
• Social media
• Wireless tech
• Toxic relationships
• Toxic work environments
• Money worries
• Relationship issues
• Death & illness in the family
• Neighbourhood problems
• Crime levels
• Poor entertainment and public service options
• Insufficient career options

The list is endless…

All of these stressors can contribute to the development of MCAS. 

Stress, at the very least, is oxidative and inflammatory, so finding ways to manage stress, and reducing stress, are deeply important. Regular exercise, eating well, getting enough sleep, and a good work to life balance, are all ways in which to reduce stress.

Using essential oils can also reduce stress levels considerably. Research has shown that essential oils can influence the HPA axis and parasympathetic nervous system, helping to lower stress hormones like cortisol.

Some of the best essential oils for reducing cortisol levels include:

• Lavender Essential Oil
• Bergamot Essential Oil
• Ylang Ylang Essential Oil
• Clary Sage Essential Oil
• Frankincense Essential Oil
• Chamomile Essential Oil
• Organic Sweet Orange Essential Oil

Please use the search box at the top of this page to research these essential oils further. 

How The Body Processes Stress

It is the author’s understanding that the body views stress in a very simplified way. In this simplified take on things, it is perceived that the body doesn’t differentiate between toxic stressors, pathogentic stressors and emotional stressors, etc… Thus, the body views all of the following simply as stressors:

• Toxic strossors: environmental contaminents: air pollution + soil pollution + contaminated water + home furnishings + personal care products + lifestyle products
• Pathogentic stressors: infectious pathogens; bacteria, fungus / yeast infections, viruses & parasites
• Emotional stressors: toxic interpersonal relationships & toxic work environments, etc…
• Energetic Stressors: wireless technologies + dirty energy + radiowaves, etc…

*Mental stressors are just as inflammatory as infections and toxcity. Over-stimulation of the limbic region of the brain – adverse chilhood events + chronic stressors + toxic relationships, etc, contribute to an over -taxed system. All provide the stimulous for our immune systems to initiate an inflammatory response in the body.

Our immune system can only cope with so many stressors before it gets overwhelmed. And, an overwhelmed immune system is what leads to Mast Cell Activation Syndrome.

This is why it is so important to remediate infections before they become chroinic, and why reducing our stress burden is so vital.

This article identifies all of the key stressors that can lead to overwhelm and an MCAS diagnosis. By reducing your exposure to the environmental stressesors, and following the protocols for dealing with pathogenic stressors, you will not only avert the potential for an MCAS diagnosis, you will also, doubtless, improve your energy levels and quality of life, considerably.

The Neurodegenerative Component Of MCAS

Neurodegenerative disease is thought to be caused by network insufficiency, where symptoms emerge from the loss of synapses, over time.

The thought processing part of our brain function relies on synapses. We start out with about 500 trillion synapses, but lose them at differing rates, dependent on a number of factors.

Synaptic losses are determined by inflammatory lifestyle exposures and inflammatory neurodegenerative factors.

Kefir has been shown to preserve brain health & reverse decline. New trials have revealed that it significantly reduces brain inflammation, boosts mitochondrial protection, and triggers powerful memory-enhancing effects, which were once thought impossible through diet alone. Source: https://www.sciencedirect.com/science/article/pii/S2949834125000133

Synapses Explained

Synapses are the fundamental units of communication within the nervous system. They allow neurons to interact and transmit information.

Synapses are effectively the communication hubs of the nervous system. They form the junctions between nerve cells. They also form junctions between a nerve cell and other cell types, such as cells within muscles and glands.

Synapses are responsible for the transmission of electrical signals and chemical signals, between these cells.

Chemical synapses are more numerous than electrical synapses. They are involved in the release of neurotransmitters, which, like hormones, are chemical messengers, responsible for maintaining homeostasis. Neurotransmitters are released from one neuron to another, via the synaptic cleft / gap between the neurons.

Electrical synapses facilitate direct, passive flow of electrical current between neurons, through specialised channels, called gap junctions. They provide more immediate communication, but are fewer in number than chemical synapses.

The strength and number of synaptic connections can change with experience, playing a crucial role in learning and memory. This means that the fundamental way in which our brain learns and forms memories, is down to our developmental exposures / activity-dependent modifications of synaptic efficacy.

Synaptic plasticity permits synapses to change their strength and number. This is a key mechanism for encoding experiences into long-term memory.

Conversely, synaptic pathology, including abnormal synaptic structures, loss of synapses, and aberrant signaling, is a common feature of many neurological conditions.

Plus, infection and/or toxicity can result in a potentialy lethal condition, known as chronic inate encephalitis.

Inate Encephalitis

The inate element of inate encephalitis relates to the inate immune system which generates inflammatory processes.

The itis in encephalitis refers to inflammation. (Any condition that ends in itis means that it is inflammatory.)

Encephalitis is a serious condition, often caused by viral infection. It describes a condition where the brain becomes inflamed. Encephalitis can equally be caused by an autoimmune response, and adverse reactions to medicines and medical proceedures.

As encephalitis is life-threatening, it requires immediate medical attention, and likely hospitalisation.

Encephalitis can also be due to bacterial or fungal infections, or even parasites.

It is characterised, in the early stages, by flu-like symptoms with fever and headache. As the condition worsens, symptoms can include; confusion, seizures, loss of consciousness, changes in personality and behavior, difficulty speaking, weakness, or loss of movement.

Treatment requires determining the root cause of the condition, which can sometimes prove difficult. This can affect long-term outcomes. Some individuals recover fully from encephalitis with few or no lasting problems. However, some can also experience lasting brain damage and other long-term challenges.

Synaptic Health & MCAS

At the outset, symptoms of neurodegenerative disorders include:

• Memory loss
• Struggling to find the right words
• Brain fog & confusion
• Fatigue

Our mitochondria produce the energy within our body. We need energy to produce new synapses. However, when our energy is being used to fuel our immune systems, we don’t have the energy for building new synapses.

Ttoxicity, infection and inflammation place too many demands on our system. Inflammation stunts energy production… the mitochondria produce less energy, when the body is inflammed.

We are either in a growth or maintainance mode. Growth means making new synapses and better conections. And, maintainance mode means that we don’t have time or energy for that.

Growth = Connection

Protection = Disconnection

Sleep Apnea & Neurodegenerative Disorders & MCAS

Sleep apnea is a key precursor to neurodegenerative decline. Sleep quality, in general, is also a major precursor to neurodegenerative decline, for the same reason.

Sleep apnea is a common cause of poor sleep quality. It often results in headaches on waking and fatigue and sometimes confusion during the day.

Getting sufficient, uninterupted sleep, is vital for our health. It is even more important than diet! This is because we heal whilst we are asleep.

Sleep can be disrupted due to inflammatory pain and infections, particularly parasite infections and mould infections. Sinusitis, and the attendant breathing difficulties can cause sleep issues, and affect oxygen levels, etc.

If you think you may have sleep apnea it is a lot more important to get it treated than you might think.

The Wild As The Wind Deep Sleep Essential Oil Blend has been developed for all kinds of sleep issues, including sleep apnea. However, as muscle tone in the troat can often be an issue, it is important to also have this investigated if you feel this is contributing to your case.

MCAS & Neurodegenerative Disorders & Menopause

Menopausal women often experience marked cognitive decline. This is because menopausal women have bioaccumulated a lot of toxicity by the time they reach their menopausal years.

For example, by our 50’s, we have sequestered considerable amounts of heavy meatals into our bones. So, when we experience the osteoclastic processes of menopause, these re-released toxic metals can gravitate towards our brain, and cause cognitive decline.

As you will likely know, heavy metals like aluminium, are implicated in neurodegenerative diseases, like Alzheimer’s.

Osteoclastic processes involve the natural breakdown of bone tissue. This process is performed by osteoclast cells, the multinucleated cells that secrete acids and enzymes to dissolve the inorganic and organic components of bone. It is crucial for:

• Bone remodeling
• Bone repair
• Maintaining calcium homeostasis

Old or damaged bone tissue is dissolved by osteoclasts, which is then replaced by healthy bone.

The process is referred to as bone reabsorption. This is because bone minerals, type I collagen, calcium, and heavy metals, are all released, from our bones, into the bloodstream. From there, the heavy metals can easily make their way to our brains.

However, bone reabsorption is an important function of the body. It contributes to calcium homeostasis, and is essential for bone remodeling.

Bone remodeling is a continuous process of bone being broken down and then being rebuilt. This ensures ongoing bone strength and adaptation in terms of load bearing.

Osteoclastic processes are also vital for bone repair. Fractured and damaged bone is dissolved by osteoclasts. The osteoblasts then lay down new bone tissue, facilitating bone healing.

Hormones like parathyroid hormone (PTH) and calcitonin regulate osteoclastic activity.

Osteoclastic processes are also involved in cytokine signaling: Cytokines are also part of our immune system. Specific cytokines, like tumour necrosis factor (TNF)-α and interleukin-1 (IL-1), can also influence osteoclast activity and differentiation.

Imbalances in osteoclastic and osteoblastic activity can lead to bone diseases, like osteoporosis, where excessive bone resorption occurs. (The breaking down of bone tissue is known as bone resorption.)

During menopause, a decline in oestrogen levels significantly impacts our bone health. This is because lowered oestrogen levels lead to increased osteoclastic activity, and a reduction in new bone formation. This imbalance results in:

• Accelerated bone resorption – weakened bones
• Bone loss and reduced bone density – making them more susceptible to fractures, particularly in weight-bearing areas like the hips and knees
• A proneness to osteoporosis

If you suffer from MCAS, all of these outcomes will be exacerbated. This is because those suffering from inflammatory conditions will experience increased osteoclast activity, which will contribute to elevated bone loss.

*Even poor diet, and lifestyle choices will contribute to bone loss during menopause.

MCAS & Neurodegenerative Disorders & Menopause = A Perfect Storm!

Limbic Region Of The Brain & MCAS

Over-stimulation of the limbic region of the brain can significantly contribute to the expression of Mast Cell Activation Syndrome.

The limbic system’s involvement in MCAS is very much a vicious cycle. It can be over-activated by the perpetual immune response experienced by those suffering from MCAS.

This over-activation of the limbic system can elevate the stress response which then further exacerbates MCAS symptoms.

The limbic system is responsible for behavior, emotional processing and stress responses, and is contained within the frontal lobe of our brain. It is the part of the brain which is most easily accessed by essential oils, when inhaled. This is why a good number of essential oils are so regularly advocated for their use in emotional and mental health conditions.

The limbic region is also the part of the brain responsible for memory and forming associations with stimuli. An astounding 5% of our DNA is devoted to olfaction, (our sense of smell). And, it is understood that smell and emotion are stored as one memory, owing to the fact that all of these activities are processed by the same part of the brain. This is why our sense of smell is so evocative of memories.

A scientific paper, published on the National Institute of Health website, entitled: Therapeutic Effect and Mechanisms of Essential Oils in Mood Disorders: Interaction between the Nervous and Respiratory Systems, states that:

In this review, we have discussed the antidepressant and anxiolytic [anti-anxiety] effects of EOs in both human clinical and animal studies. The interplay between the respiratory system and CNS was also touched upon. Through the interconnection of the two systems, EO molecules exert an effect on mood disturbances via different possible routes. Cellular and molecular events, including alteration of monoamines, neurotrophic factors and neurogenesis are potential mechanisms underlying the therapeutic effects of EOs

Key To Understanding The Above Quote:

• EOs – Essential oils
• Monoamines – a class of neurotransmitters and neuromodulators, including dopamine, norepinephrine, and serotonin, that are derived from aromatic amino acids.
• Neurotrophic factors: molecules that support the growth, survival, and differentiation of neurons. They play crucial roles in both developing and the maturation of our nervous systems. These factors, often peptides or small proteins, can influence neuron development, survival, and synaptic plasticity. Examples include neurotrophins (like NGF and BDNF), glial cell line-derived neurotrophic factor (GDNF), and ciliary neurotrophic factor (CNTF).
• Neurogenesis: growth and development of nervous tissue.

The same clinical research states that Lavender Essential Oil, Grapefruit Essential Oil and Bergamot Essential Oil exert a cortisol reducing effect, which could have clear and tangible benefits for those suffering from MCAS. [Wild As The Wind also carry organic versions of these oils.]

Cortisol is a stress hormone and very much a part of the stress response which is chronically activated in MCAS sufferers.

The limbic system, is largely composed of the amygdala, hippocampus, thalamus, hypothalamus, basal ganglia, and cingulate gyrus.

When the body experiences an immune response the limbic system may perceive this as a threat to survival. The more MCAS triggers an immune response, the more likely our limbic system will strengthen the association between this and the stress response.

This stress response can increase neurochemicals like cortisol, adrenaline, and norepinephrine, which can further amplify symptoms and hinder recovery.

The over-activation of the limbic system can contribute to neurological symptoms like:

• Anxiety
• Brain fog
• Headaches
• Sleep disturbances, according to a report from Re-origin.

Thankfully, it is possible to re-train our limbic systems, so that they respond more calmly to MCAS symptoms. This is done by establishing new associations and consciously managing stress.

There are a good number of Limbic System Retraining programs available online

However, only treating MCAS symptoms will not lead to recovery. For this, the underlying cause must be addressed.

Galectin-3

Environmental toxins and infections are the key triggers of Galectin-3, which is another element of our immune response.

When Galectin-3 is released, a cascade of inflammation is initiated in the body. This can cause chronic pain and disability in MCAS sufferers, and others. It can also cause considerable damage in the form of fibrosis, (overproduction of connective tissue), etc.

Galectins are proteins [which are] able to bind to carbohydrates (sugar molecules), [that] participate in several physiological processes, including cell migration, immune responses, and cell-to-cell interactions. Many studies show a significant increase in galectin-3, a ubiquitous beta-galactoside-binding protein involved in chronic inflammation and tissue fibrosis, in patients with fibrosis in various organs (Slack et al., 2021). In particular, galectin-3 has been associated with fibrosis.

Source: The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis: https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1430109/full

*Fibrosis is also a common complication of Polycystic Ovarian Syndrome, which is affecting 20% of women, these days. More on this later.

Galectin-3 Overview

Galectin-3 belongs to the lectin family, a group of proteins which bind to certain carbohydrates. A multifunctional protein, with widespread anatomical distribution, it is found almost everywhere in the body; in biological fluids & tissues and within cells.

It has access to both the plasma membrane and extracellular matrix.

• Plasma membrane [The plasma membrane, is also known as the cell membrane. It forms the outer boundary of a cell, separating the interior of the cell from the external environment]
• Extracellular matrix [The extracellular matrix, aso known as the ECM, is a complex network of molecules surrounding, and providing structural support for, cells within tissues and organs, ultimately providing a platform for cell-to-cell communication.

Galectin-3 is known to play a multifaceted role in various biological processes, including cell activation, inflammation, and fibrogenesis. As part of the innate immune system, it influences various aspects of defense against microbial infections:

• Acting as a pattern recognition receptor, (PRR), it recognises pathogen-associated molecular patterns (PAMPs).
• Once PAMPs are identified, Galectin-3 activates immune cells like neutrophils (white blood cells that defend against infection & inflammation) and macrophages, (another type of white blood cell), that encapsulates and kills microorganisms. They also perform a clean-up operatiion, removing dead cells, whilst also stimulating other immune system cells into action.
• Galectin-3 also modulates the activity of immune cells, more specifically: the way immune cells migrate to infection sites, activating phagocytosis*, and regulating cytokine** production.

*Phagocytosis is a cellular process. Phagocyte cells engulf large particles, such as; pathogens, foreign substances, and dead cells, in a process of endocytosis. Endocytosis denotes the process where the membrane of a cell folds inward to surround and capture a particle. Enzymes, within the phagocyte, then break down the engulfed particle, destroying it.

**Cytokines are mediators (more on these later). They are essentially signaling molecules, which are primarily proteins, that act as messengers between cells, especially within, but not exclusive to, the immune system. They regulate the growth and activity of other immune cells and blood cells, playing a key role in the immune and inflammatory responses of the body.

Galectin-3 Going Rogue?

Despite being part of the innate immune system, and designed to protect, Galectin-3 is being increasingly recognised for its involvement in the pathogenesis of several diseases, including cancer, heart failure, chronic inflammatory conditions, neurodegenerative disorders, metabolic disorders and fibrosis, etc…

The increased levels of Galectin-3 in certain diseases has led to it becoming a diagnostic marker, and a therapeutic target.

This is because it is understood to be playing a specific role in common diseases. Elevated galectin-3 levels are associated with:

Cardiovascular Disease: heart failure + arrhythmias + other cardiovascular events.

Fibrosis: Overproduction of connective tissue in various organs, including: heart + liver + kidneys + uterous, etc.

Cancer: Galectin-3 exerts an influence on: oncogenesis + cancer progression + metastasis. (The role of Galectin-3 in different cancers may be specific to each type.)

Neurodegenerative Diseases: Neuroinflammation & may exacerbate conditions like Alzheimer’s disease & Parkinson’s, etc.

Metabolic Disorders: Plays a role in the development & progression of metabolic disorders & their complications.

Reducing Galectin-3 Effects

Many essential oils are anti-inflammatory, and will exert an indirect effect on Galectin-3 production. Reducing inflammation effectively quietens down the immune response.

There are many individual essential oils, which would be helpful. Those that would be particularly beneficial are listed below, as are the essential oil blends that would exert the most benefit:

Individual Essential Oils

• Angelica Root Essential Oil
• Bergamot FCF Essential Oil
• Bergamot Mint Essential Oil
• Black Pepper Essential Oil

Essential Oil Blends

• Deep Calm Essential Oil Blend
• Deep Sleep Essential Oil Blend
• Ease Essential Oil Blend

Supplements 

Modified Citrus Pectin (MCP), is a dietary fiber that binds to the carbohydrate recognition domain of galectin-3, thereby acting as a direct inhibitor.

N-Acetyllactosamine is a nitrogen-containing disaccharide that acts as a galectin-3 inhibitor.

RN1 (Panax notoginseng) is a polysaccharide found in the flower of the Panax notoginseng plant. It is thought to bind to galectin-3 and suppress its expression, according to a study published on the National Institutes of Health (NIH) website. It also inhibits the interaction between galectin-3 and other receptors, affecting signaling pathways involved in cancer cell growth.

Mast Cells & The Immune Response

Mast cells are part of our innate immune system. More specifically, mast cells are white blood cells that are part of our ancient immune system. Because of this, mast cells respond quickly to environmental triggers, in the same way that other parts of our primitive systems do.

For example, the Amygdala, inside our brain, is part of the primitive response system, and is responsible for triggering fear, that initiates the fight or flight response.

Mast cells, despite being white blood cells, do not reside in our blood supply. As mentioned earlier, mast cells exist within the soft tissues, to protect these tissues from pathogenic infection and environmental toxins.

The way in which mast cells protect us is to de-granulate, or explode, releasing mediators which are designed to combat infection.

Histamine & Other Mediators

Mast cells synthesise and secrete toxic, pro-inflammatory mediators, which cause an up-regulation of innate immune mechanisms.

Mediators are toxic chemicals, made by the body, for the purpose of neutralising pathogenic infections.

Mediators are toxic to pathogens, so they are largely successful at remediating infections. However, they are also toxic to us.

Nevertheless, our bodies need an arsenal of chemicals that is deadly to invaders, which means necessarily using innate chemicals that are toxic to us, as well. This is ultimately the lesser of two evils as these toxic mediators can be easily cleared from the body once they have performed their task. Conversely, if pathogens persist they will do a lot more damage over time. So, the end definitely justifies the means!

Histamine, which a lot of us know, is produced to deal with allergens, is a well-known mediator. Tryptase, the enzyme released alongside histamine, is another more well-known mediator. But, we have never even heard of the vast majority of them.

There are over 1,000 different types of mediators, all of which are inflammatory.

Histamine Function

Histamine is a chemical messenger that triggers uncomfortable allergy symptoms, like itching, mucous formation, difficulty breathing, sneezing and streaming eyes and nose.

Despite the discomfort it causes, histamine plays a crucial role within our immune system. It helps to regulate inflammation, the root cause of MCAS, and it also supports digestive and brain health.

Tryptase

Tryptase, which like histamine, is stored within mast cell granules, is released when mast cells are activated by an allergic reaction or anaphylaxis.

Tests for tryptase, that reveal elevated tryptase levels in the blood, indicate mast cell degranulation, which reveals an immune response or allergic reaction.

Tryptase levels are used diagnostically to measure anaphylaxis and to investigate mastocytosis, a condition characterised by an abnormal increase in mast cells.

Other mediators that you may have heard of, include:

• Proteases
• Prostaglandin D2
• Leukotrienes
• Heparin
• Cytokines (many of which are implicated in coronary heart disease, and were commonly referred to during the coronvirus years.)

Cytokines

Many of us became aware of cytokines, and the term cytokine storm, in the first year of coronavirus. Cytokine storms were regularly referred to on the news, and were presented as the cause of breathing difficulties in corona hospital patients, a predicament that often proved fatal.

Cytokines are signalling molecules, of which there are several.

An inflammatory Cytokine is a type of Cytokine which is secreted from immune cells / Mast Cells, and certain other cell types, that promote inflammation.

Inflammatory Cytokines are predominantly produced by T helper cells (Th) and Macrophages, as well as Mast Cells, and are involved in the up-regulation of inflammatory reactions.

Like all other mediators, Inflammatory Cytokines play a role in initiating the inflammatory response and in fuelling the innate immune response. Some inflammatory Cytokines have additional roles such as acting as growth factors.

The Cytokine Storms experienced by many sufferers of coronavirus, which sometimes proved lethal, primarily took place in the lungs. As this is potentially one of the pathological outcomes of the virus it is important to mitigate this type of dangerous immune expression by intervening with protocols to:

• Reduce infection and the need for inflammatory immune expression.
• Normalise the immune response before a full blown Cytokine Storm can occur.

Clearing airways, reducing inflammation, and neutralising pathogens all increase lung capacity and reduce infection, thereby releasing the body naturally from the need to persist in mounting cytokine responses.

Components Of The Immune Response

Amaloyd Plaque

Amaloyd plaque is part of the innate immune system. It is an antimicrobial peptitide which goes to the brain to mitigate infection. It initially coats the infection, containing it, and then goes to work on killing it.

Amaloyd plaque is erroniously thought to cause Alzheimer’s. The modern medical approach to treating Alzheimer’s is to try and reduce amaloyd plaque levels, instead of dealing with the underlying infection.

As conventional medicine is ignoring the underlying infection, this remains untreated, and cognitive decline continues.

Mast Cell Activation Syndrome & Liver Health

Our liver is the only organ in our body that can completely regenerate itself. Even if we have 75% of our liver tissue removed, it would grow back within a few months.

However, liver regeneration requires specific nutrients, which sadly, a lot of us don’t consume.

The herb, Milk Thistle, provides the exact nutrients needed.

Silymarin, from Milk Thistle, creates a protective barrier around liver cells, and helps to provide the building blocks needed for new, healthy liver tissue.

MCAS & Inflammation

MCAS inflammation is expressed, in varying degrees, within a spectrum, ranging from mild to severe.

In severe cases of MCAS the sufferer is dysfunctional, in a lot of pain, due to body-wide inflammation in their joints and muscles, as well as potentially having a whole slew of allied conditions, including; *neuropathy, *Dysautonomia, gastrointestinal abnormalities, (such as *gastroparesis), alongside a completely impaired immune system. At this stage Mast Cell Activation Syndrome is very seriously debilitating, and can be life-threatening.

*Neuropathy is the medical term for nerve damage. Many people suffer from peripheral neuropathy, like those with diabetes and those who have received chemotherapy.

As the name suggests, peripheral neuropathy develops when nerves in our extremities, (hands, feet and arms), are damaged. This causes neuropathic burning pain in the nerves which transfer information between the brain and spinal cord from our skin and muscles as well as other parts of our body.

It’s estimated almost 1 in 10 people aged 55 or over are affected by peripheral neuropathy in the UK.

The most common cause of peripheral neuropathy in the UK is nerve damage from diabetes. It can also be caused by things like an injury or infection.

Diabetes is recognised as an autoimmune condition.

*Dysautonomia, or autonomic dysfunction, is a condition affecting our autonomic nervous system, (ANS), which, when healthy, regulates our stress response.  Dysautonomia , as the name suggests, is the condition whereby the autonomic nervous system does not work properly. This may affect the functioning of many major organs including our heart and bladder, as well as our intestines, sweat glands, pupils, and blood vessels.

Dysautonomia has many causes, not all of which are neuropathic.

*Gastroparesis is a condition which affects normal spontaneous movement of the muscles, or motility, in our stomach. It is a chronic condition which renders our stomach unable to empty in the normal way, resulting in food passing through slower than usual.

3 Types Of MCAS

There are three major themes of Mast Cell Activation Syndrome: Allergic + Inflammatory + Growth Dystrophic, denoted by abnormal growth or development which result in lumps bumps, nodules and cysts.

Healing From MCAS

To get well from Mast Cell Activation Syndrome it is helpful, wherever possible, to identify the specific triggers which caused each individual case of Mast Cell Activation in the first instance. However, this isn’t always possible.

Sometimes it is the genetic triggering within our mothers which cause second generational Mast Cell Activation Syndrome in offspring. There are many reasons why access to parental medical notes is not possible.

However, our gene expression is largely in a fluid state, which is referred to as epigenetics. All manner of bodily exposures are constantly epigenetically turning our genes on and off.

For example, one of the most common interactions between us and the world is the food we eat. Ultimately, food is information which directly impacts our epigenetic expression.

Eating really nutrient rich, organic food is likely to reduce gene expression which leads to ill-health, thereby reducing genetic predispositions, whereas a poor diet will leave us open to more genetic illnesses, on the basis that our pathogenic ‘switched on’ genes don’t get the information they need to switch back off again.

Some genes, however, are switched on by a parent and won’t be switched off for four, five or six generations.

Remediation of Mast Cell Activation Syndrome is usually a lengthy process. This is partly because a full medical history of the sufferer, and that of their mother, often isn’t available. Plus, testing for Mast Cell Activation Syndrome is very complex, with a lot of inaccurate results.

As well as urine and blood tests, bone marrow biopsies are also used to determine triggers by identifying mediators, but they are rarely requested by clinicians.

Usually the arrival at a Mast Cell Activation Syndrome diagnosis is a process of elimination, where tests are done for other conditions where elevated systemic inflammation is the key symptom. This avenue is particularly fruitful if tests are done for conditions where there’s haemoglobin anomalies, (red blood cell anomalies), elevated platelets, low or high white blood cell counts are recorded. [https://ashpublications.org/blood/article/122/21/5240/12408/Characterization-Of-Common-Blood-Test]

So, in the absence of all historic data, if all of the symptoms can’t be explained by another condition, but the symptoms and lab results are all indicative of Mast Cell Activation Syndrome, then you probably have Mast Cell Activation Syndrome.

**Those with PCOS are more likely to have Mast Cell Activation Syndrome, because MCAS puts women at risk of PCOS. There’s also a correlation with the stats… it’s estimated that around 20% of women have PCOS.

***Hormonal imbalances, resulting in fibrosis, endometriosis, infertility and problematic periods etc will also sometimes have Mast Cell Activation Syndrome as a precursor.

Some Of The Big Triggers Of MCAS

• Tick bites – Bartonella infection*
• Mycotoxicity – mould infection
• Viral infections, like Coronavirus
• Parasitic infection
• Trauma
• Choric Emotional toxicity from self / others / job / insufficient finances etc
• Radiation exposure
• Environmental toxins from conventional farming and industrial pollution etc
• Antibiotic use, especially long-term antibiotic Prescriptions
• Immunosuppressant drugs

Children are more susceptible to radiation as their nerves are not fully protected by myelin sheaths until they reach the age of 21.

Anyone with hyper flexibility is more susceptible to mould infections.

* Bartonellosis is an infectious disease produced by bacteria of the genus Bartonella. Bartonella species cause a wide number of diseases which include:

• Carrión’s disease
• Trench fever
• Cat-scratch disease
• Bacillary angiomatosis
• Peliosis hepatis
• Chronic bacteremia
• Endocarditis
• Chronic lymphadenopathy
• Neurological disorders.
• Trauma

However, none of these infections would bring about Mast Cell Activation Syndrome in an individual if they didn’t first have immune regulation dysfunction.

So, those who have taken a lot of antibiotics, or have been exposed to a lot of toxic chemicals, like those used in conventional farming, which destroy immune health, or who are immune-compromised in other ways, through a course of radiation and chemotherapy etc, are the ones who are going to potentially spiral out of control when exposed to any of the things in the above list.

Mycotoxic individuals with Mast Cell Activation Syndrome are also already suffering from immune dysregulation / malfunction for mycotoxicity to occur. Those with a fully functional immune system will be able to detox the mycotoxins from mould exposure without any adverse effects.

The MCAS Downward Spiral

This is all part of the Mast Cell Activation Syndrome downward spiral. A dysregulated immune system allows mould / yeast / fungal infections to get a hold systemically, which further downgrades our immunity.

In fact, mycotoxicity on the one hand, suppresses immune function and also increases Mast Cell activity, which is a real double-whammy.

Mould can be environmental, from water damaged buildings, and air-con systems, or it can be eaten in the form of commonly mould-infected foods.

Mould-Infected Foods

• Grains, particularly wheat and corn
• Coffee
• Chocolate
• Certain nuts, like Brazil nuts and Paenuts (peanut butter is a major source of mould infection)
• Soft fruits
• Cheese
• Mushrooms
• Vinegar including vinegar containing foods, such as salad dressing, ketchup, and pickles etc
• Sour cream, sour milk, and buttermilk.
• Foods made with yeast, such as breads etc. breads
• Jams, jellies and preserves
• Sauerkraut
• Cruciferous vegetables like cabbage, broccoli and cauliflower

This article mini-series reveals how to heal from a mould infection, and explains how serious mould infections can be: Toxic Mould.

MCAS Remediation

The best approach to remediation of MCAS is to calm the Mast Cells down so they stop producing the mediators, whilst also addressing the inflammation, and root infections.

Anti-histamines are useful here, as they are H1 blockers, or histamine receptor site blockers.

Hystamine receptors are given numeric values, such as H1 and H2 receptor sites.

H1 receptors are very much in evidence on our skin and respiratory system and they drive cellular migration, nociception, vasodilatation, and bronchoconstriction.

H2 receptors are mainly in the GI tract and they modify gastric acid secretion, airway mucous production, and vascular permeability.

H3 receptors play an important role in neuro-inflammatory diseases.

Natural Anti-Histamines

Luckily there are plenty of natural alternatives to prescription and pharmacological drugs when it comes to MCAS and other inflammatory, autoimmune conditions.

It is recommended that a combination of dietary supplements, herbs and essential oils are used, rather than one protocol being applied. The dietary supplements are important in all cases, and the advocated essential oils are also tremendously useful.

However, whilst there are essential oil alternatives to the listed herbs, such as Turmeric Essential Oil, Black Pepper Essential Oil, Ginger Essential Oil and Holy Basil Essential Oil, it is better to take therapeutic doses of the powdered form of these herbs and spices where these items are concerned. Please see below…

Best Supplements For MCAS

Vitamin C is considered a natural antihistamine which may help to reduce histamine in our system. This is because vitamin C reduces the amount of histamine in our bodies, when we are exposed to allergens.

This is a superior, and more natural way, of limiting the negative impacts of histamine on our system.

Conversely, conventional antihistamines interfere with natural processes, rather than working with them. They do this by blocking histamine receptors, which means that histamine is mobilised within our systems, but simply has less places to dock.

Improving natural immunity will normalise your immune response to pathogens. Improved natural immunity will reduce the inflammatory response within your body and will avoid an overwhelming immune response to pathogens.

This means you will feel less unwell when you catch a bug or get exposed to toxins. It also means you will recover more quickly and avoid potentially life-threatening, extreme immune responses.

Taking the following supplements and using the essential oils recommended below will significantly help to normalise your natural immunity. (Using the Wild As The Wind Deep Calm Essential Oil Blend is the most affordable way of using these anti-inflammatory, histamine-reducing essential oils to support natural immunity.)

Supplements For MCAS

All of the supplements listed in this section must be taken daily to achieve improved natural immunity.

For example, Vitamin C + Quercetin + Zinc permits Zinc to be delivered itra-cellulary (inside our cells) where it can eliminate infection. and prevent viral replication.

In quickly reducing infection in this way our bodies are liberated from the need to mount excessive cytokine storms and other potentially life threatening immune responses. And, of course, we will recover a lot more quickly whilst dramatically reducing the level of our suffering whilst ill.

• Vitamin C (minimum 1,000mg)
• Quercetin – anti-inflammatory and antihistamine
• Bromelain (optional)
• Vitamin D3 & Vitamin K27 – 5,000 iu of Vit D daily.
• Zinc – must be taken with Copper to avoid Copper depletion*
• Food Grade Organic Nigella Sativa Oil

*We need sufficient Copper in our systems to make best use of our Zinc levels. Supplementing with Zinc without supplementing with Copper will undermine immunity and make us ill. Copper deficiency causes a negative cascade within the body. Signs of Copper deficiency include excessive fatigue, vertigo and walking as though drunk.

2 mg of Copper along with a Zinc supplement is vitally important.

Comprehensive outcomes for Copper imbalance

Plus, Zinc, on its own, does not prevent viral replication within the cells. It needs a different supplement to be able to enter the cells of our body. Please see below.

Many of us are deficient in Vitamin D (which is actually a hormone), not least because we are deficient in Vitamin K2-7, an important nutrient needed for the absorption of Vitamin D. We are not making enough Vitamin D from the sun due to the use of sun creams, and we have insufficient Vitamin K2-7 in the modern Western diet.

The sun is too low in the sky to provide enough strength for us to make Vitamin D between October and April in the UK.

Most immune-deficient people and Mast Cell Activation Syndrome sufferers have a Vitamin D deficiency. Every Mast Cell has a Vitamin D receptor on it. Thus, Vitamin D₃ is profoundly important. Vitamin D₃ supplementation should be accompanied by Vitamin K₂₇. Follow the link for more information.

Food Grade Organic Nigella Sativa Oil may act as a Zinc Ionophore in the same way Vitamin C and Quercetin, when taken together with Zinc, combine to make Zinc Ionophores.

Zinc, on its own, has no ability to work intracellularly.

When infected with a virus, viral replication takes place inside our cells, which renders the Zinc ineffectual. However, if we take Zinc with Nigella Sativa Oil and / or Quercetin and Vitamin C, these can act as Zinc Ionophores, which enable the Zinc to pass through the lipid membrane of our cells to fight the good fight!

Nigella Sativa Oil has also be shown to prevent tissue damage within lungs, heart and blood vessels when people are infected with spike proteins, either naturally, or after having an injection.

Spike protein infection can lead to myocarditis and pericarditis, serious lung damage and PoTS. This can occur as a consequence of natural or engineered spike proteins.

Learn more about this in the Food Grade Organic Nigella Sativa Oil article.

For further information about the processes of Zinc ionophores this article is helpful: https://clinicaltrials.gov/ct2/show/NCT04468139

It’s also important to supplement with Copper if you are taking high levels of Zinc daily, over an extended period of time. Copper deficiency leads to fatigue and dizziness, and a general sense of being inebriated! Long term deficiencies can result in several severe outcomes, including mental health issues and chronic fungal infections.

Other Important Supplements

Magnesium deficiency is also incredibly widespread, especially amongst those who routinely eat processed food and pre-made meals. These products are hiding a lot of ingredients which are profoundly detrimental to our health, including Palm oil and vegetable fats. Another hidden ingredient, which is profoundly bad for our health, is refined sugar.

It takes 47 molecules of Magnesium to process one molecule of sugar, leaving a lot of us manifestly deficient in this vitally important mineral. Magnesium is required for thousands of fundamental processes within our bodies, so insufficient Magnesium results in body-wide problems and malfunctions.

Learn more about the importance of Magnesium  in Sleep & The Mineral Connection. This article details why those who are mineral deficient, especially Magnesium, suffer from insomnia and often anxiety too.

*It’s possible to buy Quercetin & Bromelain supplements where these two important constituents are combined.

Pineapple is the highest food source of Bromelain, but it also contains pro-inflammatory constituents and so should be avoided.

Strawberries are also to be avoided as they cause Mast Cells in our gastrointestinal tract to release Histamine.

Eating an alkalising, inflammation reducing diet is also important. Sometimes it’s what you leave out, rather than what you include in your diet which can make a big difference in symptomatic expression.

Also supplementing with activated Glutathione, the most efficient antioxidant there is, to help reduce our toxic burden is also a good idea. An alternative to this is taking N-Acetyl Cysteine which helps to create Glutathione naturally within our bodies, or we can use Milk Thistle, (see herbs).

Taking Omega 3 also helps reduce inflammation in our bodies. We eat too much Omega 6 and Omega 9 fatty acids, which are pro-inflammatory. These inflammatory lipids / fats, like vegetable oils, such as sunflower and corn oil, for example, are often touted as being healthy, but they are causing inflammation and immune issues within our bodies. Omega 3 helps to balance these out, thereby reducing inflammation.

Many people take fish oil for this. But, our oceans are horrifically polluted and fish colonies are on the verge of collapse, so taking 3 tbsp of Linseed, which has been soaked overnight, and then blended into a smoothie the next day, is a vastly better option.

Linseeds are practically 50% Omega 3 oil.

Linseeds have also been clinically proven to be equivalent to HRT in terms of their ability to regulate hormones.

There are many natural health doctors advocating for the complete removal of vegetable fats / seed oils from our diets.

Best Protocols For Reversing MCAS

Mitigating MCAS and neurodegenerative disorders is all about quieting down the immune response and lowering inflammation.

Lowering inflammation is the first step, as this allows us to hone in on, and identify some of the root causes of the issue.

Become insulin sensitive

Become mildly ketogenic – you can do this through diet or use exogenous ketones

Check oral health for infection, and remediate.

Chronic pathogens that are really common include candida albicans

c-difficile (due to antibiotic use -many people develop)

Chronic nasal and jaw infections

Remidiate Herpes Simplex

P Gingervalis

Sinusitis

Bartonella – tick borne illness

Mycotoxins

C. difficile infection (CDI), often associated with antibiotic use, arises when the balance of bacteria in the gut is disrupted, allowing C. difficile to overgrow. This can lead to diarrhea and potentially severe complications like pseudomembranous colitis. Antibiotic-associated diarrhea due to C. difficile occurs in around 20-30% of cases. How C. difficile Infection Develops Due to Antibiotic Use: Disrupted Gut Microbiome: Antibiotics, especially broad-spectrum ones, can kill off beneficial bacteria in the gut, creating an opportunity for C. difficile to flourish. C. difficile Overgrowth: The increased numbers of C. difficile can lead to the release of toxins that damage the colon lining. Symptoms: Common symptoms include watery diarrhea, abdominal cramping, and fever. Potential Complications: If left untreated, CDI can progress to more severe conditions like pseudomembranous colitis, toxic megacolon, and even sepsis. Risk Factors: Antibiotic Use: The primary risk factor is recent or current antibiotic use, especially broad-spectrum antibiotics. Other Factors: Increased age, frailty, previous CDI, co-morbidity, and immunocompromised individuals are also at higher risk. Healthcare Settings: Hospital settings, with higher antibiotic use and potential for transmission, are also associated with a greater risk of CDI. Prevention and Treatment: Preventing C. difficile Infection: Taking antibiotics as prescribed, being mindful of hygiene practices, and avoiding unnecessary antibiotic use can help reduce the risk. Treatment: If C. difficile infection is suspected or diagnosed, a stool sample is taken for testing, and the antibiotic may be stopped if appropriate. Specific antibiotics like metronidazole or vancomycin are used to treat CDI

We have neuro stem cells! So, the brain can regenerate. We can unburden our mitochondria and create new ones, so we can start producing more energy.

Peptides can help rebuild our bodies.

Peptides, are short chains of amino acids that act as building blocks for proteins like collagen and elastin, which are crucial for skin’s structure, texture, and resilience.

In skincare, they work as messengers, stimulating skin cells to perform specific functions like boosting collagen and elastin production, potentially reducing the appearance of wrinkles and improving skin elasticity.

Cerapeptides, a combination of ceramides and peptides, offer multiple benefits for the skin, including improved hydration, strengthened skin barrier, and enhanced elasticity.

Best Herbs & Spices For MCAS

• Turmeric (with Black Pepper to increase uptake). This can be found in supplement form if you prefer. It confers myriad benefits including being a phenomenal anti-inflammatory. Turmeric can prevent the release of Histamine from Mast Cells and can even inhibit anaphylactic reactions.
• Ginger is anti-inflammatory, antidiabetic, antioxidant, digestive, anti-nausea and may also help chemotherapy-related nausea. Ginger is an efficient antihistamine and provides immune support. It also reduces oxidative stress and aids weight loss. Take up to 2g of Ginger Powder in homemade juices, smoothies and teas.
• Holy Basil, or Tulsi, is an adaptogenic, antihistamine herb which provides very effective Mast Cell support. It contains antimicrobial, antibiotic, antiviral, anti-inflammatory, febrifuge (antipyretic /fever-reducing) properties and Vitamin C. More specifically, it down-regulates asthma and respiratory illness. And whilst it’s possible, but difficult, to find Tulsi Essential Oil, using the powdered herb is preferential in this instance. Holy Basil Essential Oil has high levels of the constituent Eugenol, which is known to cause irritation in some people and requires intermittent use. Holy Basil is in this herb list rather than the essential oil list as it can be taken daily and is unlikely to cause irritation.
• Astragalus membranaceus, a traditional Chinese medicine, has some impressive, scientifically supported, effects on immune function, and histamine in particular. It may help reduce allergy symptoms, prevent histamine release, whilst also helping to stabilise Mast Cells. It is also helpful for healing the digestive system.
• Pau D’arco extract contains antibacterial, antifungal and anti-inflammatory properties. Published research suggests Pau D’arco can inhibit the release of certain inflammatory mediators.
• Milk Thistle, also known as Holy Thistle, is considered the “King of detoxifying herbs”, which specifically boosts Glutathione in the body. I like to use it in tincture form, and I advocate we all add it to our daily detox regime!
• Nettle Tea is a great natural anti-histamine, and is very beneficial in many other ways.
• Watercress is another potent anti-histamine which is packed full of nutrients. Just add this peppery, green leaf to your salads, making sure to eat the stalks too.

Using Binders To Detox

When using any preparation or food to kill pathogens, like parasites, viruses, mould and bacterial overgrowth, or when removing heavy metals and other toxins, it is important to use binders to neutralise them.

I recommend the use of apple or grapefruit pectin as a binder for toxic waste so we can safely pass these harmful substances from the body. This is especially important for heavy metals and mycotoxic elements.

If you are supplementing with minerals or doing green juices with green powders this will mobilise heavy metals etc. If these aren’t neutralised with a binder they will find another location within our bodies to deposit themselves. Heavy metals really like to find their way into our brains where they contribute towards all manner of neurodegenerative conditions.

Best Essential Oils For MCAS

The essential oils listed here are thought to be helpful for Mast Cell Activation Syndrome and Histamine Intolerance.

However, the information provided is not intended to replace the medical directives of your healthcare provider. This information is not meant for the diagnosis of health issues. If you are pregnant, have serious or multiple health concerns, consult with your healthcare provider before using essential oils or associated products. If you experience any complications or adverse reactions contact your healthcare provider.

Wild As The Wind produce a Deep Calm Essential Oil Blend, which is a proprietary blend of organic and wildcrafted versions of some of the following aromatherapy oils.

Deep Calm Essential Oil Blend may help with the symptomatic reduction of inflammatory disorders including allergies, chemical sensitisation, Cytokine activity, emotional issues, (anxiety, depression, panic attacks and PTSD), and may even help alleviate insomnia and restless leg syndrome etc.

Deep Calm Essential Oil Blend contains essential oils which are thought to be anti-inflammatory, antihistamine, antiviral, antimicrobial, antibacterial and antifungal.

Deep Calm Essential Oil Blend may help with all autoimmune and respiratory conditions.

Deep Calm Essential Oil Blend contains the following organic essential oils:

• Organic Bergamot FCF Essential Oil
• Organic Lavender Essential Oil
• Organic Rosemary Essential Oil
• Organic Thyme Red Essential Oil
• Copaiba Balsam Essential Oil
• Frankincense Serrata Essential Oil
• *Organic German Chamomile Essential Oil
• Organic Spearmint Essential Oil
• Organic Myrrh Essential Oil

*Wildcrafted Organic Essential Oil

As an undiluted essential oil blend Deep Calm Essential Oil Blend can be used in diffusers, and inhaled straight from the bottle.

Deep Calm Essential Oil Blend must be diluted in a good carrier oil before being applied to your skin. Raspberry Seed Oil is recommended as it absorbs beautifully, and is suitable for facial application to relieve sinuses etc.

Contraindications & Cautions

Deep Calm Essential Oil Blend is contraindicated for pregnant women and nursing mothers.

This preparation is NOT phototoxic, but it must be properly diluted before topical application. Consult Using Essential Oils for more information.

Full List Of Beneficial Essential Oils For MCAS

Frankincense Serrata Essential Oil

I have seen Frankincense Serrata Essential Oil time and again helping relieve the suffering of those with seasonal allergies and headaches.

Frankincense Serrata Essential Oil assists with the following:

•     Inflammation
•     Mast Cell support
•     Immune system
•     Respiratory support
•     Stress relief
•     Microbial infection

Frankincense Serrata Essential Oil can be inhaled for instant relief, especially for migraines and seasonal and other allergies. When diluted properly it can be applied topically to local areas at a 5% dilution in a good carrier oil.

Organic Bergamot FCF Essential Oil

Organic Bergamot FCF Essential Oil has been conclusively proven to have pharmacological *antinociceptive effectiveness both in nociceptive and in neuropathic pain models. However, the antinociceptive properties of Organic Bergamot FCF Essential Oil for the purpose of inhalation have not been widely investigated. Nevertheless, the molecules in aromatherapy oils are known to be so small that they work intracellularly. This means they pass through the blood brain barrier with ease.

*Antinociception, also known as nocioception or nociperception, is the bodily response to potentially toxic stimuli, like harmful chemicals and mycotoxicity etc…

Organic Thyme Red Essential Oil

Organic Thyme Red Essential Oil is an important aromatherapy oil on this list as it has some unique properties. For example, it is a natural Progesterone, which is extremely important when it comes to reducing stress and inflammatory levels in women. (Women use Progesterone to make the stress hormone Cortisol, which leaves many women Progesterone deficient.)

Organic Thyme Red Essential Oil is also a Mast Cell stabiliser. It is both a Histamine blocker (prevents Histamine from docking in Histamine receptors), and it also helps to prevent the release of Histamine from Mast Cells.

Thyme Red Aromatherapy Oil also provides nervous system support, reduces symptoms of chronic fatigue syndrome, supports heart health + blood pressure management, and Like Rosemary Aromatherapy Oil it also supports brain health and memory.

Thyme Red Essential Oil is the variety of Thyme Essential Oil which is least likely to cause skin and nasal irritation. Thyme Essential Oil, especially Thyme White Essential Oil has been known to cause nasal irritation in some who inhale it directly from the bottle.

However, when blended with other essential oils this outcome is significantly reduced.

Copaiba Balsam Essential Oil

Copaiba Balsam Essential Oil, like Myrrh Essential Oil, and Frankincense Essential Oil, is a potent antioxidant. It is also powerfully anti-inflammatory.

Copaiba Balsam Essential Oil is variously; antibacterial, anti-inflammatory, anti-fungal, anti-microbial, antioxidant, anti-parasitic, antiseptic, astringent, calmative, circulatory, diaphoretic, (induces perspiration), diurectic, emmenagogue, hepato-protetive, stimulant, vulnerary, (wound healing).

Organic Lavender Essential Oil

Organic Lavender Essential Oil is very beneficial for inflammation, allergies and mitigating respiratory cytokines.

It is an important aromatherapy oil for reducing Mast Cell Activation and histamine intolerance.

•    Supports Mast Cells
•    Supports natural immune function
•     Reduces stress and anxiety
•     Reduces insomnia
•     Soothes sore muscles & joints

Organic Lavender Essential Oil can be applied topically or inhaled directly from the bottle, or it can be used in a diffuser.

Organic Rosemary Essential Oil

Organic Rosemary Essential Oil is excellent for supporting respiratory and systemic health. It is a rich source of antioxidants and anti-inflammatory compounds, thought to help boost immunity and improve blood circulation.

Organic Rosemary Essential Oil also contains the important constituent alpha-pinene which has been shown to possess antispasmodic and antihistamine properties.

Organic Myrrh Essential Oil

Organic Myrrh Essential Oil has been shown to support Mast Cells in several ways. In particular it has been proven to reduce inflammatory cytokine levels.

Organic Myrrh Essential Oil is a powerful anti-inflammatory, with potent antifungal and skin healing properties.

Organic German Chamomile Essential Oil

Organic German Chamomile Essential Oil reduces Histamine production and is also anti-inflammatory, anti-anxiety and anti-depressant. It also supports restful sleep and helps with insomnia.

Organic Spearmint Essential Oil

Organic Spearmint Essential Oil is a potent aromatherapy oil with many applications. It has been shown, in peer reviewed research, to promote testosterone reduction, (the main cause of PCOS), and for regulating blood sugar levels.

Organic Spearmint Essential Oil is analgesic, anti-allergenic, anti-asthmatic, antibacterial, anti-fungal, anti-inflammatory, antioxidant,  anti-spasmodic, antiseptic, carminative, decongestant, digestive, diuretic, emmenagogue, expectorant, relaxant, stimulant, stomachic.

Essential Oils To Avoid If You Have MCAS & Histamine Intolerance

There are some essential oils you should avoid if you have Mast Cell Activation Syndrome and Histamine Intolerance, because they will exert effects which may make your symptoms worse.

• Cinnamon Essential Oil (histamine liberating)
• Citrus Essential Oils should not be used internally
• Clove Essential Oil (histamine liberating)
• Nutmeg Essential Oil (histamine liberating)

Also avoid German Chamomile Essential Oil if you are allergic to Ragwort.

Essential Oils For Immune Support

When our immune systems are working over time, we need all of the support we can get. Bacterial infections present a particular problem due to the antibiotic-resistance of many common pathogens. Please read Essential Oils For Antibiotic Resistant Bacterial Infections to learn how essential oils can keep you more well protected.

Five Allies Essential Oil Blends For Immune Support

Wild As the Wind produce a number of proprietary Five Allies Essential Oil Blends blends to help address some of the immune problems we face in our modern world. This includes emotional issues, especially where compromised hormone function, and the adverse effects of wireless technologies are concerned.

Wireless technologies are known to exacerbate inflammation, increase mould / fungal infections and undermine our immune systems by up to 40%.

These Five Allies Essential Oil Blends preparations are antibacterial, antiviral, anti-fungal and anti-parasitic.

• Five Allies 2020 Essential Oil Blend
• Five Allies 2022 Essential Oil Blend
• Five Gentle Allies Essential Oil Blend

However, only one of these options is suitable for people with MCAS:

Five Gentle Allies Essential Oil Blends

Five Allies 2020 Essential Oil Blend and Five Allies 2022 Essential Oil Blend both contain Organic Cinnamon Bark Essential Oil and Organic Clove Bud Essential Oil, which are both histamine liberating.

Essential Oils Versus Perfumes

Most people who are allergic to perfumes are NOT allergic to perfumes. This is because many perfumes are toxic, and using the right aromatherapy oils in the right way is a non-toxic experience.

However, a small number of people are allergic or intolerant of the odd essential oil, so always do a patch test before using properly diluted essential oils for topical application. If there is irritation when inhaling essential oils from the bottle or in a diffuser, then your aromatherapy blend or individual essential oil is not suitable for you.

Hypersensitive people cannot tolerate using essential oils, and will need to detox the toxic load on their bodies before this situation will be reversed.